Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

被引：10

作者：

Capelle, Christophe M. ^{[1
,2
]}

Cire, Severine ^{[1
]}

Domingues, Olivia ^{[1
]}

Ernens, Isabelle ^{[3
]}

Hedin, Fanny ^{[4
]}

Fischer, Aurelie ^{[3
]}

Snoeck, Chantal J. ^{[1
]}

Ammerlaan, Wim ^{[5
]}

Konstantinou, Maria ^{[4
]}

Grzyb, Kamil ^{[6
]}

Skupin, Alexander ^{[6
,7
]}

Carty, Cara L. ^{[8
]}

Hilger, Christiane ^{[1
]}

Gilson, Georges ^{[9
]}

Celebic, Aljosa ^{[10
]}

Wilmes, Paul ^{[2
,6
]}

Del Sol, Antonio ^{[6
,11
,12
]}

Kaplan, Ian M. ^{[8
]}

Betsou, Fay ^{[5
,13
]}

Abdelrahman, Tamir ^{[13
]}

Cosma, Antonio ^{[4
]}

Vaillant, Michel ^{[10
]}

Fagherazzi, Guy ^{[3
]}

Ollert, Markus ^{[1
,14
,15
]}

Hefeng, Feng Q. ^{[1
]}

机构：

[1] Luxembourg Inst Hlth LIH, Dept Infect & Immun, Esch Sur Alzette, Luxembourg

[2] Univ Luxembourg, Fac Sci Technol & Med, Esch Sur Alzette, Luxembourg

[3] Luxembourg Inst Hlth, Dept Precis Hlth, Strassen, Luxembourg

[4] Luxembourg Inst Hlth, Natl Cytometry Platform, Esch Sur Alzette, Luxembourg

[5] Integrated BioBank Luxembourg IBBL, Dudelange, Luxembourg

[6] Univ Luxembourg, Luxembourg Ctr Syst Biomed LCSB, Belvaux, Luxembourg

[7] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[8] Adapt Biotechnol, Seattle, WA USA

[9] Ctr Hosp Luxembourg CHL, Luxembourg, Luxembourg

[10] Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Translat Med Operat Hub, Strassen, Luxembourg

[11] CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain

[12] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

[13] Lab Natl Sante LNS, Dudelange, Luxembourg

[14] Univ Southern Denmark, Odense Res Ctr Anaphylaxis ORCA, Dept Dermatol, Odense, Denmark

[15] Univ Southern Denmark, Odense Res Ctr Anaphylaxis ORCA, Allergy Ctr, Odense, Denmark

来源：

CELL REPORTS MEDICINE | 2022年 / 3卷 / 04期

基金：

欧洲研究理事会; 欧盟地平线“2020”;

关键词：

SYSTEMS IMMUNOLOGY; T-CELLS; SARS-COV-2; GENERATION; INFECTION; RESPONSES; AGE;

D O I：

10.1016/j.xcrm.2022.100600

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudinal cohort of 63 mild and 15 hospitalized patients versus 14 asymptomatic and 26 household controls. We observe a transient increase of IP10/CXCL10 and interferon -b levels, coordinated responses of dominant SARS-CoV-2-specific CD4 and fewer CD8 T cells, and various antigen-presenting and antibody-secreting cells in mild patients within 3 days of PCR diagnosis. The frequency of key innate immune cells and their functional marker expression are impaired in hospitalized patients at day 1 of inclusion. T cell and dendritic cell responses at day 1 are highly predictive for SARS-CoV2-specific antibody responses after 3 weeks in mild but not hospitalized patients. Our systematic analysis reveals a combinatorial picture and trajectory of various arms of the highly coordinated early-stage immune responses in mild COVID-19 patients.

引用

页数：24

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