Highly efficient synthesis of chiral /%-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2

被引：10

作者：

Liu, Yufeng ^{[1
,2
]}

Wang, Linzhou ^{[1
]}

Li, Yingjun ^{[3
,4
,5
]}

Ma, Baode ^{[1
,2
]}

Chen, Gen-Qiang ^{[1
,2
,4
,5
]}

Zhang, Xumu ^{[1
,2
,3
]}

机构：

[1] Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Med X Pingshan, Shenzhen 518000, Peoples R China

[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China

[3] Shenzhen Bay Lab, Shenzhen 518132, Peoples R China

[4] Acad Adv Interdisciplinary Studies, Shenzhen 518000, Peoples R China

[5] Southern Univ Sci & Technol, Shenzhen 518000, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2022年 / 3卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Asymmetric reductive amination; Chiral; %-amino phosphine; Ruthenium-catalysed; Ammonium salt; ENANTIOSELECTIVE HYDROGENATION;

D O I：

10.1016/j.gresc.2022.06.005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and enantioselective method for the asymmetric reductive amination of /%-keto phosphine derivatives was disclosed, and the corresponding /%-amino phosphine oxides could be obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 97% ee). Moreover, the reaction worked well on a gram scale, indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.

引用

页码：298 / 301

页数：4

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