Apathy and cortical atrophy in Alzheimer's disease

被引：81

作者：

Tunnard, C. ^{[1
]}

Whitehead, D. ^{[1
]}

Hurt, C. ^{[1
]}

Wahlund, L. O. ^{[5
]}

Mecocci, P. ^{[6
]}

Tsolaki, M. ^{[7
]}

Vellas, B. ^{[8
]}

Spenger, C. ^{[5
]}

Kloszewska, I. ^{[9
]}

Soininen, H. ^{[10
]}

Lovestone, S. ^{[2
,3
,4
]}

Simmons, A. ^{[1
,2
,3
,4
,11
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC Ctr Neurodegenerat, London SE5 8AF, England

[2] Maudsley NHS Fdn Trust, Beckenham, Kent, England

[3] NIHR, Specialist Biomed Res Ctr Mental Hlth, S London, England

[4] Kings Coll London, London, England

[5] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Sect Clin Geriatr, Stockholm, Sweden

[6] Univ Perugia, Inst Gerontol & Geriatr, Perugia, Italy

[7] Aristotle Univ Thessaloniki, Dept Neurol, Thessaloniki, Greece

[8] Univ Toulouse 3, Toulouse Gerontopole Univ Hopsital, INSERM, U 558, F-31062 Toulouse, France

[9] Med Univ Lodz, Dept Old Age Psychiary & Psychot Disorders, Lodz, Poland

[10] Univ Kuopio, Univ Hosp, Dept Neurol, Kuopio 70211, Finland

[11] Kings Coll London, Inst Psychiat, Ctr Neuroimaging Sci, London WC2R 2LS, England

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 2011年 / 26卷 / 07期

关键词：

Alzheimer's disease; apathy; MRI; cortical thickness; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; NEUROPSYCHIATRIC SYMPTOMS; GEOMETRICALLY ACCURATE; INVENTORY; DEPRESSION; TRIALS; SPECT; SCALE;

D O I：

10.1002/gps.2603

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: Apathy has been reported as the most prevalent behavioural symptom experienced in Alzheimer's disease (AD), associated with greater functional decline and caregiver distress. The aim of the current study was to investigate structural correlates of apathy in AD using magnetic resonance imaging (MRI) regional volume and regional cortical thickness measures. Methods: Semi-structured interviews were conducted with 111 AD patients and their caregivers as part of the European multi-centre study AddNeuroMed. Apathy was measured using the apathy domain of the Neuropsychiatric Inventory (NPI). All AD patients were scanned using a 1.5T MRI scanner and the images analysed using an automated analysis pipeline. Results: We found apathy to be the most prevalent neuropsychiatric symptom occurring in 57% of patients. Apathetic patients had significantly greater cortical thinning in left caudal anterior cingulate cortex (ACC) and left lateral orbitofrontal cortex (OFC), as well as left superior and ventrolateral frontal regions, than those without apathy symptoms. Conclusions: Apathy is mediated by frontocortical structures but this is specific to the left hemisphere at least for patients in the mild to moderate stages of AD. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：741 / 748

页数：8

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