Challenges in infant immunity: implications for responses to infection and vaccines

被引：316

作者：

PrabhuDas, Mercy ^{[1
]}

Adkins, Becky ^{[2
]}

Gans, Hayley ^{[3
]}

King, Christopher ^{[4
]}

Levy, Ofer ^{[5
,6
]}

Ramilo, Octavio ^{[7
,8
]}

Siegrist, Claire-Anne ^{[9
]}

机构：

[1] NIAID, Div Allergy Immunol & Transplantat, NIH, Bethesda, MD 20892 USA

[2] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

[3] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA

[4] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[5] Childrens Hosp Boston, Dept Med, Boston, MA USA

[6] Harvard Univ, Sch Med, Boston, MA USA

[7] Nationwide Childrens Hosp, Ctr Vaccines & Immun, Columbus, OH USA

[8] Ohio State Univ, Columbus, OH 43210 USA

[9] Univ Geneva, Ctr Vaccinol & Neonatal Immunol, Geneva, Switzerland

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 03期

关键词：

RECENT THYMIC EMIGRANTS; CD4(+) T-CELLS; ADAPTIVE IMMUNITY; VACCINATION; AGE; DEFICIENCY; EXPRESSION; NEWBORNS; INNATE;

D O I：

10.1038/ni0311-189

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infections in infants continue to be an important cause of morbidity and mortality worldwide. Understanding the immune mechanisms that operate in infants is necessary for the development of new approaches to improve the health of infants around the world.

引用

页码：189 / 194

页数：6

共 25 条

[1] Neonatal adaptive immunity comes of age [J].

Adkins, B ;

Leclerc, C ;

Marshall-Clarke, S .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :553-564

[2] Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model [J].

Bogaert, Debby ;

Weinberger, Daniel ;

Thompson, Claudette ;

Lipsitch, Marc ;

Malley, Richard .

INFECTION AND IMMUNITY, 2009, 77 (04) :1613-1622

[3] Maternal HIV infection and placental malaria reduce transplacental antibody transfer and tetanus antibody levels in newborns in Kenya [J].

Cumberland, Phillippa ;

Shulman, Caroline E. ;

Maple, P. A. Chris ;

Bulmer, Judith N. ;

Dorman, Edgar K. ;

Kawuondo, Ken ;

Marsh, Kevin ;

Cutts, Felicity T. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (04) :550-557

[4] Deficiency of the humoral immune response to measles vaccine in infants immunized at age 6 months [J].

Gans, HA ;

Arvin, AM ;

Galinus, J ;

Logan, L ;

DeHovitz, R ;

Maldonado, Y .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (06) :527-532

[5] Improving cellular therapy for primary immune deficiency diseases: Recognition, diagnosis, and management [J].

Griffith, Linda M. ;

Cowan, Morton J. ;

Notarangelo, Luigi D. ;

Puck, Jennifer M. ;

Buckley, Rebecca H. ;

Candotti, Fabio ;

Conley, Mary Ellen ;

Fleisher, Thomas A. ;

Gaspar, H. Bobby ;

Kohn, Donald B. ;

Ochs, Hans D. ;

O'Reilly, Richard J. ;

Rizzo, J. Douglas ;

Roifman, Chaim M. ;

Small, Trudy N. ;

Shearer, William T. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (06) :1152-1160

[6] Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function [J].

Haines, Christopher J. ;

Giffon, Thierry D. ;

Lu, Li-Sheng ;

Lu, Xiaowei ;

Tessier-Lavigne, Marc ;

Ross, Douglas T. ;

Lewis, David B. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (02) :275-285

[7] Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine [J].

Ivanov, Ivaylo I. ;

Frutos, Rosa de Llanos ;

Manel, Nicolas ;

Yoshinaga, Keiji ;

Rifkin, Daniel B. ;

Sartor, R. Balfour ;

Finlay, B. Brett ;

Littman, Dan R. .

CELL HOST & MICROBE, 2008, 4 (04) :337-349

[8] Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guerin Vaccination of Newborns [J].

Kagina, Benjamin M. N. ;

Abel, Brian ;

Scriba, Thomas J. ;

Hughes, Elizabeth J. ;

Keyser, Alana ;

Soares, Andreia ;

Gamieldien, Hoyam ;

Sidibana, Mzwandile ;

Hatherill, Mark ;

Gelderbloem, Sebastian ;

Mahomed, Hassan ;

Hawkridge, Anthony ;

Hussey, Gregory ;

Kaplan, Gilla ;

Hanekom, Willem A. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (08) :1073-1079

[9] Booster Vaccination After Neonatal Priming with Acellular Pertussis Vaccine [J].

Knuf, Markus ;

Schmitt, Heinz-Josef ;

Jacquet, Jeanne-Marie ;

Collard, Alix ;

Kieninger, Dorothee ;

Meyer, Claudius U. ;

Siegrist, Claire-Anne ;

Zepp, Fred .

JOURNAL OF PEDIATRICS, 2010, 156 (04) :675-678

[10] Innate immunity of the newborn: basic mechanisms and clinical correlates [J].

Levy, Ofer .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (05) :379-390

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