The Rational Design and Biological Mechanisms of Nanoradiosensitizers

被引：28

作者：

Sun, Hainan ^{[1
,2
]}

Wang, Xiaoling ^{[1
]}

Zhai, Shumei ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Colloid & Interface Chem, Jinan 250100, Shandong, Peoples R China

[2] Shandong Vocat Coll Light Ind, Zibo 255300, Shandong, Peoples R China

来源：

NANOMATERIALS | 2020年 / 10卷 / 03期

基金：

中国国家自然科学基金;

关键词：

nanoradiosensitizers; radiosensitization; radiotherapy; biological mechanisms; physicochemical properties; NEGATIVE BREAST-CANCER; TARGETED GOLD NANOPARTICLES; ZINC-OXIDE NANOPARTICLES; SIZE-DEPENDENT TOXICITY; SILVER NANOPARTICLES; DNA-DAMAGE; TUMOR-CELLS; SELENIUM NANOPARTICLES; OXIDATIVE STRESS; RADIOSENSITIVITY ENHANCEMENT;

D O I：

10.3390/nano10030504

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Radiotherapy (RT) has been widely used for cancer treatment. However, the intrinsic drawbacks of RT, such as radiotoxicity in normal tissues and tumor radioresistance, promoted the development of radiosensitizers. To date, various kinds of nanoparticles have been found to act as radiosensitizers in cancer radiotherapy. This review focuses on the current state of nanoradiosensitizers, especially the related biological mechanisms, and the key design strategies for generating nanoradiosensitizers. The regulation of oxidative stress, DNA damage, the cell cycle, autophagy and apoptosis by nanoradiosensitizers in vitro and in vivo is highlighted, which may guide the rational design of therapeutics for tumor radiosensitization.

引用

页数：30

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