Emulation Differences vs. Biases When Calibrating Real-World Evidence Findings Against Randomized Controlled Trials

被引：35

作者：

Franklin, Jessica M. ^{[1
]}

Glynn, Robert J. ^{[1
]}

Suissa, Samy ^{[2
,3
,4
]}

Schneeweiss, Sebastian ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA

[2] McGill Univ, Dept Epidemiol, Montreal, PQ, Canada

[3] McGill Univ, Dept Biostat, Montreal, PQ, Canada

[4] McGill Univ, Dept Occupat Hlth, Montreal, PQ, Canada

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 107卷 / 04期

关键词：

D O I：

10.1002/cpt.1793

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Actionable real-world evidence (RWE) requires accurate estimation of causal treatment effects. Calibration of RWE against randomized controlled trials (RCTs) is sometimes done to demonstrate that RWE can support the same causal conclusion as RCTs. Disagreements can occur when studies in each pair asked different questions in different populations or due to the presence of residual bias. Distinguishing among reasons for differences will impact the level of confidence in RWE.

引用

页码：735 / 737

页数：3

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