Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration

被引:79
作者
Parrell, Benjamin [1 ,2 ]
Agnew, Zarinah [3 ]
Nagarajan, Srikantan [4 ]
Houde, John [3 ]
Ivry, Richard B. [2 ]
机构
[1] Univ Delaware, Dept Linguist & Cognit Sci, Newark, DE 19716 USA
[2] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA
[3] Univ Calif San Francisco, Dept Otolaryngol, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
ataxic dysarthria; cerebellum; feedback control; feedforward control; speech; speech motor control; SENSORIMOTOR ADAPTATION; AUDITORY-FEEDBACK; SENSORY PREDICTION; INTERNAL-MODELS; COMPENSATION; ERROR; INVOLVEMENT; PERCEPTION; RESPONSES; DYNAMICS;
D O I
10.1523/JNEUROSCI.3363-16.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cerebellum has been hypothesized to form a crucial part of the speech motor control network. Evidence for this comes from patients with cerebellar damage, who exhibit a variety of speech deficits, as well as imaging studies showing cerebellar activation during speech production in healthy individuals. To date, the precise role of the cerebellum in speech motor control remains unclear, as it has been implicated in both anticipatory (feedforward) and reactive (feedback) control. Here, we assess both anticipatory and reactive aspects of speech motor control, comparing the performance of patients with cerebellar degeneration and matched controls. Experiment 1 tested feedforward control by examining speech adaptation across trials in response to a consistent perturbation of auditory feedback. Experiment 2 tested feedback control, examining online corrections in response to inconsistent perturbations of auditory feedback. Both male and female patients and controls were tested. The patients were impaired in adapting their feedforward control system relative to controls, exhibiting an attenuated anticipatory response to the perturbation. In contrast, the patients produced even larger compensatory responses than controls, suggesting an increased reliance on sensory feedback to guide speech articulation in this population. Together, these results suggest that the cerebellum is crucial for maintaining accurate feedforward control of speech, but relatively uninvolved in feedback control.
引用
收藏
页码:9249 / 9258
页数:10
相关论文
共 48 条
[1]   Cerebellar contributions to speech production and speech perception: psycholinguistic and neurobiological perspectives [J].
Ackermann, Hermann .
TRENDS IN NEUROSCIENCES, 2008, 31 (06) :265-272
[2]   The contribution of the cerebellum to speech production and speech perception: Clinical and functional imaging data [J].
Ackermann, Hermann ;
Mathiak, Klaus ;
Riecker, Axel .
CEREBELLUM, 2007, 6 (03) :202-213
[3]   Learning to predict the future: the cerebellum adapts feedforward movement control [J].
Bastian, Amy J. .
CURRENT OPINION IN NEUROBIOLOGY, 2006, 16 (06) :645-649
[4]  
Bates D., 2014, J Stat Softw, DOI [DOI 10.18637/JSS.V067.I01, 10.18637/jss.v067.i01]
[5]   An fMRI investigation of syllable sequence production [J].
Bohland, Jason W. ;
Guenther, Frank H. .
NEUROIMAGE, 2006, 32 (02) :821-841
[6]   Flexible explicit but rigid implicit learning in a visuomotor adaptation task [J].
Bond, Krista M. ;
Taylor, Jordan A. .
JOURNAL OF NEUROPHYSIOLOGY, 2015, 113 (10) :3836-3849
[7]   Voice F0 responses to manipulations in pitch feedback [J].
Burnett, TA ;
Freedland, MB ;
Larson, CR ;
Hain, TC .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1998, 103 (06) :3153-3161
[8]   Size of Error Affects Cerebellar Contributions to Motor Learning [J].
Criscimagna-Hemminger, Sarah E. ;
Bastian, Amy J. ;
Shadmehr, Reza .
JOURNAL OF NEUROPHYSIOLOGY, 2010, 103 (04) :2275-2284
[9]   Influence of vision on upper limb reaching movements in patients with cerebellar ataxia [J].
Day, BL ;
Thompson, PD ;
Harding, AE ;
Marsden, CD .
BRAIN, 1998, 121 :357-372
[10]   Neural correlates of reach errors [J].
Diedrichsen, J ;
Hashambhoy, Y ;
Rane, T ;
Shadmehr, R .
JOURNAL OF NEUROSCIENCE, 2005, 25 (43) :9919-9931