Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids

被引：1

作者：

AlZeera, Abdulla J. ^{[1
,2
]}

Alkhaja, Aysha ^{[3
]}

Noor, Dana H. ^{[4
,5
]}

Alsaffar, Sayed Mohamed R. ^{[6
,7
]}

机构：

[1] Med Univ Bahrain, Royal Coll Surg Ireland, Internal Med, Busaiteen, Bahrain

[2] Dr Jamal Al Zeera Med Ctr, Family Med, Isa Town, Bahrain

[3] Salmaniya Med Complex, Neurol, Manama, Bahrain

[4] King Hamad Univ Hosp, Med, Busaiteen, Bahrain

[5] Med Univ Bahrain, Royal Coll Surg Ireland, Med, Busaiteen, Bahrain

[6] Salmaniya Med Complex, Manama, Bahrain

[7] Ibn Hayan Med Ctr, Neurol, Manama, Bahrain

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2021年 / 13卷 / 10期

关键词：

neuroimaging; demyelination; adult-onset; central nervous system; acute disseminated encephalomyelitis (adem); RETROSPECTIVE COHORT; PLASMA-EXCHANGE; ADEM;

D O I：

10.7759/cureus.18669

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated phenomenon characterized by demyelination of the central nervous system that displays numerous manifestations. It predominantly presents in children with a mean age range of five to eight years. ADEM remains a diagnosis of exclusion based on clinical and radiographic progression. Thus, it poses a diagnostic challenge. ADEM has been shown to be very responsive to steroids and exchange therapy. Here, we present an unusual case of ADEM in a 50-year-old female patient who, despite receiving an entire course of IV methylprednisolone and other conventional treatment methods, did not respond to the treatment.

引用

页数：6

共 15 条

[1] Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study [J].

Absoud, M. ;

Parslow, Rc ;

Wassmer, E. ;

Hemingway, C. ;

Duncan, H. P. ;

Cummins, C. ;

Lim, M. J. .

MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (10) :1258-1261

[2] Acute disseminated encephalomyelitis: Treatment guidelines [J].

Alexander, M. ;

Murthy, J. M. K. .

ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2011, 14 :S60-S64

[3]

Anilkumar AC., 2021, Acute disseminated encephalomyelitis

[4] Acute disseminated encephalomyelitis associated with tetanus vaccination [J].

Bolukbasi, O ;

Ozmenoglu, M .

EUROPEAN NEUROLOGY, 1999, 41 (04) :231-232

[5] Role of MRI in the differentiation of ADEM from MS in children [J].

Callen, D. J. A. ;

Shroff, M. M. ;

Branson, H. M. ;

Li, D. K. ;

Lotze, T. ;

Stephens, D. ;

Banwell, B. L. .

NEUROLOGY, 2009, 72 (11) :968-973

[6] Short term outcome of ADEM: Results from a retrospective cohort study from South India [J].

Iype, Mary ;

Kunju, P. A. Mohammed ;

Saradakutty, Geetha ;

Anish, T. S. ;

Sreedharan, Mini ;

Ahamed, Shahanaz M. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2017, 18 :128-134

[7] Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice [J].

Katz-Levy, Y ;

Neville, KL ;

Girvin, AM ;

Vanderlugt, CL ;

Pope, JG ;

Tan, LJ ;

Miller, SD .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (05) :599-610

[8] Plasma exchange for severe attacks of CNS demyelination: Predictors of response [J].

Keegan, M ;

Pineda, AA ;

McClelland, RL ;

Darby, CH ;

Rodriguez, M ;

Weinshenker, BG .

NEUROLOGY, 2002, 58 (01) :143-146

[9] Disease course and outcome of acute disseminated encephalomyelitis is more severe in adults than in children [J].

Ketelslegers, I. A. ;

Visser, I. E. R. ;

Neuteboom, R. F. ;

Boon, M. ;

Catsman-Berrevoets, C. E. ;

Hintzen, R. Q. .

MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (04) :441-448

[10] A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children [J].

Manguinao, Michael ;

Krysko, Kristen M. ;

Maddike, Sai ;

Rutatangwa, Alice ;

Francisco, Carla ;

Hart, Janace ;

Chong, Janet ;

Graves, Jennifer S. ;

Waubant, Emmanuelle .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 35 :50-54

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