Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis

被引：60

作者：

Zizzo, Gaetano ^{[1
]}

De Santis, Maria ^{[1
]}

Bosello, Silvia Laura ^{[1
]}

Fedele, Anna Laura ^{[1
]}

Peluso, Giusy ^{[1
]}

Gremese, Elisa ^{[1
]}

Tolusso, Barbara ^{[1
]}

Ferraccioli, GianFranco ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Dept Rheumatol, CIC, I-00168 Rome, Italy

来源：

CLINICAL IMMUNOLOGY | 2011年 / 138卷 / 01期

关键词：

Th17; Th1; TCR-zeta; ZAP-70; Arthritis; Disease activity; Inflammation; Microcrystal; RHEUMATOID-ARTHRITIS; TH17; CELLS; PROINFLAMMATORY CYTOKINES; IL-17; INTERLEUKIN-17; EXPRESSION; BLOOD; FIBROBLASTS; IMMUNITY; MUTATION;

D O I：

10.1016/j.clim.2010.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed peripheral blood (PB) and synovial fluid (SF) mononuclear cells from 16 rheumatoid arthritis (RA), 9 spondyloarthritis (SpA), 3 microcrystal arthritis patients, to define the presence of Th17 and Th1 and their relationship with inflammatory activity, and TCR-zeta chain and ZAP-70 levels. Th17 were significantly higher in SF than in PB and more abundant in microcrystal arthritis patients compared to the other groups. Irrespectively of the diagnosis, SF Th17 percentages correlated with joint (SF total leukocyte count, neutrophil percentage) and systemic (C reactive protein [CRP], fibrinogen, erythrocyte sedimentation rate) inflammation markers. SF Th1 percentages directly correlated with inflammation and disease activity (CRP, swollen joint count [SJC]) indices in SpA, but not in RA patients. These observations support the role of Th17 in the pathogenesis of inflammatory arthritides. The TCR-zetad(dim) lymphocytes in SF were found to produce the highest amounts of cytokines including IL-17, whereas no ZAP-70 impairment was associated to Th17. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：107 / 116

页数：10

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