Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling

被引：26

作者：

Diaz, David Diaz ^{[1
,2
]}

Morin, Emmanuelle ^{[3
,4
]}

Schoen, Eva M. ^{[1
]}

Budin, Ghyslain ^{[4
]}

Wagner, Alain ^{[4
]}

Remy, Jean-Serge ^{[3
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany

[2] Univ Zaragoza, CSIC, Inst Ciencias Mat Aragon, E-50009 Zaragoza, Spain

[3] Fac Pharm, F-67000 Strasbourg, France

[4] Fac Pharm, UMR 7199, Lab Funct ChemoSyst, F-67000 Strasbourg, France

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 03期

关键词：

SELF-ASSEMBLED HYDROGEL; CLICK CHEMISTRY; ACID; DERIVATIVES; ENTRAPMENT; ORGANOGELS; PHASE; SIZE; GELS;

D O I：

10.1039/c0jm03399e

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We describe a general user-friendly platform for fine-tuning the drug release properties of low-molecular-weight hydrogels by a combination of supramolecular co-assembly of complementary molecular structures and controlled photochemical thiol-ene cross-linking. Other critical features such as thermomechanical stability and morphology of the nanostructured hydrogels are also tailored by this approach.

引用

页码：641 / 644

页数：4

共 5 条

[1] Mechanical Properties of Low-Molecular-Weight Peptide Hydrogels Improved by Thiol-Ene Click Chemistry
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LANGMUIR, 2023, 39 (47) : 16750 - 16759
[2] Low-Molecular-Weight Supramolecular Hydrogels for Sustained and Localized in Vivo Drug Delivery
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[3] The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels
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[4] Modulation of mechanical properties of low molecular weight supramolecular hydrogels of calcium cholate by drugs of varying hydrophobicity: Effect on drug release, antioxidant, and antibacterial properties
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JOURNAL OF MOLECULAR LIQUIDS, 2024, 409
[5] Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release
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COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 165 : 144 - 149

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