AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging

被引：116

作者：

Jiang, Shuai ^{[1
,2
]}

Li, Tian ^{[3
]}

Yang, Zhi ^{[3
]}

Yi, Wei ^{[4
]}

Di, Shouyin ^{[5
]}

Sun, Yang ^{[6
]}

Wang, Dongjin ^{[7
]}

Yang, Yang ^{[1
,3
]}

机构：

[1] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Dept Aerosp Med, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[5] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China

[6] Fourth Mil Med Univ, Xijing Hosp, Dept Geriatr, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

[7] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Thorac & Cardiovasc Surg, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2017年 / 38卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

AMP-activated protein kinase; Fibrosis; Fibrogenesis; Aging; Inflammation; Excessive extracellular matrix; ACTIVATED PROTEIN-KINASE; TRANSMEMBRANE CONDUCTANCE REGULATOR; IDIOPATHIC PULMONARY-FIBROSIS; VENTRICULAR HYPERTROPHY; MICE; INFLAMMATION; DYSFUNCTION; INHIBITION; STRESS; INJURY;

D O I：

10.1016/j.arr.2017.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibrosis is a common process characterized by excessive extracellular matrix (ECM) accumulation after inflammatory injury, which is also a crucial cause of aging. The process of fibrosis is involved in the pathogenesis of most diseases of the heart, liver, kidney, lung, and other organs/tissues. However, there are no effective therapies for this pathological alteration. Annually, fibrosis represents a huge financial burden for the USA and the world. 5'-AMP-activated protein kinase (AMPK) is a pivotal energy sensor that alleviates or delays the process of fibrogenesis. In this review, we first present basic background information on AMPK and fibrogenesis and describe the protective roles of AMPK in three fibrogenic phases. Second, we analyze the protective action of AMPK during fibrosis in myocardial, hepatic, renal, pulmonary, and other organs/tissues. Third, we present a comprehensive discussion of AMPK during fibrosis and draw a conclusion. This review highlights recent advances, vital for basic research and clinical drug design, in the regulation of AMPK during fibrosis. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：18 / 27

页数：10

共 94 条

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