The impact of HPV vaccination beyond cancer prevention: effect on pregnancy outcomes

被引：4

作者：

Yuill, Susan ^{[1
,2
]}

Velentzis, Louiza S. ^{[1
,3
]}

Smith, Megan ^{[1
]}

Egger, Sam ^{[1
]}

Wrede, C. David ^{[4
,5
]}

Bateson, Deborah ^{[6
,7
]}

Arbyn, Marc ^{[8
,9
]}

Canfell, Karen ^{[1
]}

机构：

[1] Univ Sydney, Daffodil Ctr, 153 Dowling St, Sydney, NSW 2011, Australia

[2] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia

[3] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[4] Royal Womens Hosp, Dept Oncol & Dysplasia, Melbourne, Vic, Australia

[5] Univ Melbourne, Melbourne Med Sch, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[6] Family Planning NSW, Ashfield, NSW, Australia

[7] Univ Sydney, Fac Med & Hlth, Sch Med, Discipline Obstet Gynaecol & Neonatol, Sydney, NSW, Australia

[8] Belgian Canc Ctr, Unit Canc Epidemiol, Sciensano, Brussels, Belgium

[9] Univ Ghent, Dept Human Struct & Repair, Fac Med & Hlth Sci, Ghent, Belgium

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2021年 / 17卷 / 10期

基金：

英国医学研究理事会; 欧盟地平线“2020”;

关键词：

HPV vaccination; adverse pregnancy outcomes; preterm births; small for gestational age; FOR-GESTATIONAL-AGE; HUMAN-PAPILLOMAVIRUS VACCINE; LOW-BIRTH-WEIGHT; ELECTROSURGICAL EXCISION PROCEDURE; 2006 CONSENSUS GUIDELINES; SPONTANEOUS PRETERM BIRTH; RISK-FACTORS; CERVICAL-CANCER; BACTERIAL VAGINOSIS; OBSTETRIC OUTCOMES;

D O I：

10.1080/21645515.2021.1936860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

While the benefits of human papillomavirus (HPV) vaccination relating to cervical cancer prevention have been widely documented, recent published evidence is suggestive of an impact on adverse pregnancy outcomes (APOs) in vaccinated mothers and their infants, including a reduction in rates of preterm births and small for gestational age infants. In this review, we examine this evidence and the possible mechanisms by which HPV vaccination may prevent these APOs. Large-scale studies linking HPV vaccination status with birth registries are needed to confirm these results. Potential confounding factors to consider in future analyses include other risk factors for APOs, and historical changes in both the management of cervical precancerous lesions and prevention of APOs. If confirmed, these additional benefits of HPV vaccination in reducing APO rates will be of global significance, due to the substantial health, social and economic costs associated with APOs, strengthening the case for worldwide HPV immunization.

引用

页码：3562 / 3576

页数：15

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