Mitochondrial DNA origins of the Latvian clefting population

被引：2

作者：

Vieira, Alexandre R. ^{[2
]}

Pliss, Liana ^{[1
]}

Pelnena, Inese ^{[1
]}

Krumina, Astrida ^{[3
]}

Baumanis, Viesturs ^{[1
]}

Lace, Baiba ^{[1
]}

机构：

[1] Latvian Biomed Res & Study Ctr, Riga, Latvia

[2] Univ Pittsburgh, Sch Dent Med, Pittsburgh, PA USA

[3] Riga Stradins Univ, Sci Lab Human Genet, Riga, Latvia

来源：

MITOCHONDRION | 2011年 / 11卷 / 02期

关键词：

Cleft lip/palate; Mitochondrial haplogroups; SUSCEPTIBILITY LOCUS; CHROMOSOME; 8Q24; LIP; PALATE; MTDNA; EUROPE; REGION; ASSOCIATION; DUPLICATION; WESTERN;

D O I：

10.1016/j.mito.2010.10.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：357 / 359

页数：3

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