fMRI and cognitive dysfunction in schizophrenia

被引:43
作者
Mitchell, RLC
Elliott, R
Woodruff, PWR
机构
[1] Univ Manchester, Neurosci & Psychiat Unit, Manchester M13 9PT, Lancs, England
[2] Univ Sheffield, Acad Dept Psychiat, Sheffield S5 7JT, S Yorkshire, England
关键词
D O I
10.1016/S1364-6613(00)01599-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Despite being one of the most prevalent psychiatric conditions, schizophrenia is still poorly understood, with no clear objective biological marker. The advent of neuroimaging has enabled in vivo investigations to complement older techniques, and has revealed important insights. fMRI provides a means to assess the neurobiological theory that schizophrenia is caused by abnormal fronto-temporal lobe connections. In studies of language abnormalities, fMRI can explicitly assess the hypothesis that the normal lateralization of language is reversed in schizophrenia. Longitudinal fMRI studies, and studies examining the effects of medication, suggest that the technique has further potential to advance our understanding of this complex disorder.
引用
收藏
页码:71 / 81
页数:11
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