Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

被引：12

作者：

Pan, Nianjuan ^{[1
]}

Liu, Chunyi ^{[1
]}

Wu, Ruirui ^{[1
]}

Fei, Qiang ^{[1
]}

Wu, Wenneng ^{[1
]}

机构：

[1] Guiyang Univ, Food & Pharmaceut Engn Inst, Guiyang, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2022年 / 10卷

关键词：

4-thiadiazole; pyrimidine; design; synthesis; antifungal activity; BIOLOGICAL-ACTIVITY; DISCOVERY; WILT;

D O I：

10.3389/fchem.2022.922813

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against Botrytis cinereal (B. cinereal), Botryosphaeria dothidea (B. dothidea), and Phomopsis sp. were determined using the poison plate technique. Biological test results showed that compound 6h revealed lower EC50 values (25.9 and 50.8 mu g/ml) on Phompsis sp. than those of pyrimethanil (32.1 and 62.8 mu g/ml).

引用

页数：5

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