PROLIFERATIVE ACTIVITY AND DIAGNOSTIC DELAY IN ORAL CANCER

被引：26
作者：
Seoane, Juan [1 ]
Pita-Fernandez, Salvador [2 ]
Gomez, Iria [1 ]
Vazquez, Ines [3 ]
Lopez-Cedrun, Jose Luis [3 ]
De Agustin, Domingo [4 ]
Varela-Centelles, Pablo [1 ]
机构：
[1] Univ Santiago de Compostela, Dept Stomatol, Sch Med & Dent, Santiago De Compostela 15782, A Coruna, Spain
[2] CHUAC, Stat & Epidemiol Unit, La Coruna 15008, Spain
[3] CHUAC, Dept Oral & Maxillofacial Surg, La Coruna 15008, Spain
[4] Cent Univ Hosp Def, Pathol Sect, Madrid 28047, Spain
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 10期
关键词：
mouth neoplasms; early detection of cancer; Ki-67; antigen; prognosis; survival; SQUAMOUS-CELL CARCINOMA; RISK-FACTORS; TUMOR; NECK; HEAD; STAGE; PATIENT; EPIDEMIOLOGY; STATISTICS; PROGNOSIS;
D O I：
10.1002/hed.21338
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Tumor stage may relate to the chronology of neoplasm growth and has been used as an outcome variable when studying diagnostic delay in oral cancer. However, tumor growth rate may act as a confounding factor. Methods. We reviewed a total of 63 incident cases of oral cancer. The variables considered for the study included age, sex, smoking history, tumor site, TNM stage, Ki-67 score, and diagnostic delay. Results. Significant differences between survivors and exitus were found in terms of tumor stage at diagnosis (I-II vs III-IV), sex, and Ki-67 scores. When the analysis was adjusted for tumor stage at diagnosis (I-II vs III-IV), proliferative activity resulted to be an independent prognostic factor for survival, whereas diagnostic delay did not influence survival. Conclusion. These results seem to suggest that survival from oral cancer is affected more by the biology of the cancer (rapid tumor growth) than by diagnostic delay. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1377-1384, 2010
引用
收藏
页码：1377 / 1384
页数：8
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