Three-Component One-Pot Reactions of 2-Trifluoromethyl-N-nosylaziridine, Primary Amines, and Vinylsulfonium Salts for Convenient Access to CF3-Containing Piperazines

被引：4

作者：

Hirotaki, Kensuke ^{[1
]}

Irie, Akiko ^{[1
]}

Nakamura, Yuki ^{[1
]}

Hanamoto, Takeshi ^{[1
]}

机构：

[1] Saga Univ, Dept Chem & Appl Chem, Grad Sch Sci & Engn, Honjyo Machi 1, Saga 8408502, Japan

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 11期

关键词：

fluorine; aziridine; vinylsulfonium salt; cyclization; piperazine; regioselectivity; FLUORINE; DERIVATIVES; STRATEGIES; CHEMISTRY; ANALOGS; ACIDS;

D O I：

10.1055/s-0036-1558963

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoromethylated piperazines were readily synthesized with excellent regioselectivity in high yields by the sequential reaction of 2-trifluoromethylated N-nosylaziridine (2-CF3-N-Ns-aziridine) with various primary amines, followed by treatment with vinylsulfonium salts, in one pot.

引用

页码：2488 / 2494

页数：7

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