Autophagy in mammalian development and differentiation

被引：1192

作者：

Mizushima, Noboru ^{[1
]}

Levine, Beth ^{[2
,3
,4
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan

[2] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

BROWN ADIPOSE-TISSUE; TRANSCRIPTION FACTOR NRF2; LIPID DROPLET FORMATION; BETA-CELL MASS; ERYTHROID-CELLS; MITOCHONDRIAL CLEARANCE; RETICULOCYTE MATURATION; ORGANELLE DEGRADATION; EMBRYONIC-DEVELOPMENT; PROTEIN-DEGRADATION;

D O I：

10.1038/ncb0910-823

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been known for many decades that autophagy, a conserved lysosomal degradation pathway, is highly active during differentiation and development. However, until the discovery of the autophagy-related (ATG) genes in the 1990s, the functional significance of this activity was unknown. Initially, genetic knockout studies of ATG genes in lower eukaryotes revealed an essential role for the autophagy pathway in differentiation and development. In recent years, the analyses of systemic and tissue-specific knockout models of ATG genes in mice has led to an explosion of knowledge about the functions of autophagy in mammalian development and differentiation. Here we review the main advances in our understanding of these functions.

引用

页码：823 / 830

页数：8

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