New N-heterocyclic carbene ligand and its application in asymmetric nickel-catalyzed aldehyde/alkyne reductive couplings

被引：155

作者：

Chaulagain, Mani Raj ^{[1
]}

Sormunen, Grant J. ^{[1
]}

Montgomery, John ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 31期

关键词：

D O I：

10.1021/ja072992f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new chiral N-heterocyclic carbene ligand has been prepared and examined in nickel-catalyzed, asymmetric reductive couplings of aldehydes and alkynes. In comparison with related structures that have been largely examined in asymmetric ring-closing metathesis reactions, the new ligand provides superior yields and enantioselectivities in the nickel-catalyzed reductive couplings. The scope of asymmetric couplings in intermolecular variants as well as a 14-membered macrocyclization is illustrated.

引用

页码：9568 / +

页数：3

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