Peritubular endothelium: The Achilles heel of the kidney?

被引：48
作者：
Rabelink, T. J. [1 ]
Wijewickrama, D. C. [1 ]
de Koning, E. J. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Einthoven Ctr Expt Vasc Med & Diabet, Dept Nephrol, NL-2300 RC Leiden, Netherlands
来源：
KIDNEY INTERNATIONAL | 2007年 / 72卷 / 08期
关键词：
endothelium; end-stage renal disease; tubular epithelium; vascular;
D O I：
10.1038/sj.ki.5002414
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The development of renal ischemia has been postulated to be a main cause of the progressive nature of kidney diseases. In recent years, it has become clear that inappropriate and sustained activation of the endothelium could mediate this phenomenon. Endothelial activation will result in leucostasis and can compromise peritubular flow. The associated sustained redox signaling will also accelerate the development of endothelial senescence. In addition, risk factors for renal disease progression can reduce endothelial repair. In the course of these events, loss of capillary structure and rarefaction develops, which drives the further development of nephron loss. In this mini review, the evidence for this pathophysiological concept as well as the possibility to detect such endothelial activation in the clinical arena is summarized.
引用
收藏
页码：926 / 930
页数：5
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