Antiangiogenesis in swine ovarian follicle: A potential role for 2-methoxyestradiol

被引：33
作者：
Basini, Giuseppina
Bussolati, Simona
Santini, Sujen Eleonora
Bianchi, Federica
Careri, Maria
Mangia, Alessandro
Musci, Marilena
Grasselli, Francesca
机构：
[1] Univ Parma, Sez Fisiol Vet, Dipartimento Prod Anim Biotecnol Vet Qualita & Si, I-43100 Parma, Italy
[2] Univ Parma, Dipartimento Chim Gen & Inorgan, I-43100 Parma, Italy
来源：
STEROIDS | 2007年 / 72卷 / 08期
关键词：
granulosa cell; angiogenesis; VEGF; 2-methoxyestradiol; superoxide anion; superoxide dismutase activity;
D O I：
10.1016/j.steroids.2007.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inhibition of angiogenesis is an important new approach for cancer treatment and the research on this topic deserve special attention. 2-Methoxyestradiol (2-ME), a molecule shown to possess antiangiogenic activity, is a naturally occurring derivative of estradiol which can be potentially produced in the ovarian follicle. This study was therefore aimed firstly to asses 2-ME content in swine follicular fluid. Moreover, we evaluated the effect of this substance on VEGF production, superoxide anion generation (O-2(-)) and superoxide dismuatase activity in granulosa cells. Our data evidence that 2-ME is present in follicular fluid where it potentially acts as a physiological inhibitor of angiogenesis by reducing VEGF production by granulosa cells: this effect could be mediated by a decrease of O-2(-) generation. (C) 2007 Elsevier Inc. All rights reserved.
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收藏
页码：660 / 665
页数：6
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