Immunological study of IFNβ-1a-treated and untreated multiple sclerosis patients:: Clarifying IFN mechanisms and establishing specific dendritic cell immunotherapy
被引:11
作者:
Berghella, AM
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Berghella, AM
Totaro, R
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Totaro, R
Pellegrini, P
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Pellegrini, P
Contasta, I
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Contasta, I
Russo, T
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Russo, T
Carolei, A
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Carolei, A
Adorno, D
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机构:CNR, ITOI, IT-67100 Laquila, Italy
Adorno, D
机构:
[1] CNR, ITOI, IT-67100 Laquila, Italy
[2] Univ Aquila, Dipartimento Neurol, I-67100 Laquila, Italy
Objectives: A comparative immunological evaluation of multiple sclerosis ( MS) patients receiving IFNbeta treatment and patients who are not receiving treatment may help clarify IFNbeta neurological mechanisms and lead the way to an effective dendritic cell ( DC) immunotherapy. This type of study helps clarify the pathological function of T cells and DCs within the TH1/TH2/TH3 network as well as the specific interactions between TH1/TH2/TH3 cytokines implicated in MS pathological mechanisms and determine the best way of reestablishing the TH1/TH2/TH3 network equilibrium. Methods: We studied network interactions between TH1/TH2/TH3 cytokine levels in serum and supernatants of whole blood and CD14+ monocyte-derived DCs in the remission phase of the disease and in correlation to the Expanded Disability Status Scale (EDSS). Results: We found that TH1 dysregulation results in a disruption of the maturation and activation of dendritic and T cells, and a lack of T-regulating cells for the induction of self-tolerance; IFNbeta mechanisms restore regulation by reestablishing the network balance but fail to resolve the disease completely due to in vivo IL12p70 network interactions leading to the deletion of self-aggressive cells. Conclusions: Our results indicate that a specific DC immunotherapy could cure rather than treat MS. The best point to reestablish the normal physiological cycle is at the immature DC stage which can be done in vitro with treated peripheral blood CD14+ cells and used in vivo to stimulate the expansion of specific regulatory T cells. Copyright (C) 2005 S. Karger AG, Basel.
机构:
Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, SwedenKarolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Huang, YM
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Hussien, Y
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Hussien, Y
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Yarilin, D
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Yarilin, D
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Xiao, BG
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Xiao, BG
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Liu, YJ
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Liu, YJ
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Link, H
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Huang, YM
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Stoyanova, N
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Stoyanova, N
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Jin, YP
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Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Jin, YP
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Teleshova, N
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Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Teleshova, N
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Hussien, Y
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Hussien, Y
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Xiao, BG
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Xiao, BG
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Fredrikson, S
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Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Fredrikson, S
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Link, H
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
机构:
Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, SwedenKarolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Huang, YM
;
Hussien, Y
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Hussien, Y
;
Yarilin, D
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Yarilin, D
;
Xiao, BG
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Xiao, BG
;
Liu, YJ
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
Liu, YJ
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Link, H
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机构:Karolinska Inst, Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Stockholm, Sweden
机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Huang, YM
;
Stoyanova, N
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Stoyanova, N
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Jin, YP
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Jin, YP
;
Teleshova, N
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Teleshova, N
;
Hussien, Y
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Hussien, Y
;
Xiao, BG
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Xiao, BG
;
Fredrikson, S
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机构:
Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden
Fredrikson, S
;
Link, H
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Huddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, SwedenHuddinge Univ Hosp, Div Neurol, Neuroimmunol Unit, Karolinska Inst, Stockholm, Sweden