A thiocoumarin-based colorimetric and ratiometric fluorescent probe for Hg2+ in aqueous solution and its application in live-cell imaging

被引：48
作者：
Qin, Siyao [1 ]
Chen, Bo [1 ]
Huang, Jing [1 ]
Han, Yifeng [1 ]
机构：
[1] Zhejiang Sci Tech Univ, Key Lab Adv Text Mat & Mfg Technol, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 15期
关键词：
LIVING CELLS; MERCURY IONS; SELECTIVE DETECTION; HYDROGEN-SULFIDE; HYPOCHLOROUS ACID; HIGH-SENSITIVITY; RATIONAL DESIGN; FRET SYSTEM; RHODAMINE; CHEMODOSIMETER;
D O I：
10.1039/c8nj01491d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new intramolecular charge transfer (ICT) based colorimetric and ratiometric fluorescent chemodosimeter for the detection of Hg2+ has been rationally designed and developed. The probe operates via the specific mercury-promoted desulfurization reaction of thiocoumarin to coumarin and exhibits high selectivity and sensitivity in almost pure aqueous solution (containing only 1% DMSO) with a Low detection Limit of 1.85 ppb. Furthermore, the probe was successfully used for the fluorescence imaging of Hg2+ in Live cells.
引用
收藏
页码：12766 / 12772
页数：7
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