The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization

被引：17
作者：
Wilkins, Luke R. [1 ]
Stone, James R. [1 ]
Mata, Jaime [1 ]
Hawrylack, Alisha [1 ]
Kubicka, Ewa [2 ]
Brautigan, David L. [2 ]
机构：
[1] Univ Virginia Hlth Syst, Dept Radiol & Med Imaging, 1215 Lee St,Box 800170, Charlottesville, VA 22908 USA
[2] Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA USA
来源：
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2017年 / 28卷 / 10期
基金：
美国安德鲁·梅隆基金会;
关键词：
HEPATOCELLULAR-CARCINOMA; RABBIT MODEL; LIVER-CANCER; THERAPY; CHEMOEMBOLIZATION; EFFICACY; TUMOR;
D O I：
10.1016/j.jvir.2017.04.005
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access; arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal refiux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents.
引用
收藏
页码：1467 / 1471
页数：5
相关论文
共 14 条
[1]   Animal models of cancer in interventional radiology [J].
Aravalli, Rajagopal N. ;
Golzarian, Jafar ;
Cressman, Erik N. K. .
EUROPEAN RADIOLOGY, 2009, 19 (05) :1049-1053
[2]   Transduction efficacy, antitumoral effect, and toxicity of adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir therapy of hepatocellular carcinoma:: The woodchuck animal model [J].
Bilbao, R ;
Gérolami, R ;
Bralet, MP ;
Qian, C ;
Tran, PL ;
Tennant, B ;
Prieto, J ;
Bréchot, C .
CANCER GENE THERAPY, 2000, 7 (05) :657-662
[3]  
BUENDIA MA, 1994, PRIMARY LIVER CANC E, P211
[4]   Development of an Animal Model for Radiofrequency Ablation of Primary, Virally Induced Hepatocellular Carcinoma in the Woodchuck [J].
Burke, Charles T. ;
Cullen, John M. ;
State, Andrei ;
Gadi, Sashi ;
Wilber, Kathy ;
Rosenthal, Michael ;
Bulysheva, Anna ;
Pease, Anthony ;
Mauro, Mathew A. ;
Fuchs, Henry .
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2011, 22 (11) :1613-1618
[5]  
Cote PJ, 1997, VIRAL HEPATITIS LIVE, P128
[6]   Chemoembolization of liver tumor in a rabbit model: Assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis [J].
Geschwind, JFH ;
Artemov, D ;
Abraham, S ;
Omdal, D ;
Huncharek, MS ;
McGee, C ;
Arepally, A ;
Lambert, D ;
Venbrux, AC ;
Lund, GB .
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2000, 11 (10) :1245-1255
[7]   Woodchuck hepatitis virus-induced carcinoma as a relevant natural model for therapy of human hepatoma [J].
Gouillat, C ;
Manganas, D ;
Zoulim, F ;
Vitrey, D ;
Saguier, G ;
Guillaud, M ;
Ain, JF ;
DuqueCampos, R ;
Jamard, C ;
Praves, M ;
Trepo, C .
JOURNAL OF HEPATOLOGY, 1997, 26 (06) :1324-1330
[8]   New intra-arterial drug delivery system for the treatment of liver cancer: Preclinical assessment in a rabbit model of liver cancer [J].
Hong, K ;
Khwaja, A ;
Liapi, E ;
Torbenson, MS ;
Georgiades, CS ;
Geschwind, JFH .
CLINICAL CANCER RESEARCH, 2006, 12 (08) :2563-2567
[9]   Transarterial chemoembolization alone and in combination with other therapies: a comparative study in an animal HCC model [J].
Maataoui, A ;
Qian, J ;
Vossoughi, D ;
Khan, MF ;
Oppermann, E ;
Bechstein, WO ;
Vogl, TJ .
EUROPEAN RADIOLOGY, 2005, 15 (01) :127-133
[10]  
National Research Council Committee on New and Emerging Models in Biomedical and Behavioral Research, 1998, BIOM MOD RES CURR NE
12