Effects of triethylene tetraamine on the G-quadruplex structure in the human c-myc promoter

被引：10

作者：

Yin, Fei

Liu, Jianhui ^{[1
]}

Deng, Xiaohong

Wang, Jingyun

机构：

[1] Chongqing Technol & Business Univ, Res Ctr Pharmaceut Chem & Chemobiol, Chongqing, Peoples R China

[2] Chongqing Technol & Business Univ, Coll Environm & Bioengn, Chongqing 400067, Peoples R China

[3] Dalian Univ Technol, Coll Environm & Bioengn, Dalian 116023, Peoples R China

来源：

JOURNAL OF BIOCHEMISTRY | 2007年 / 141卷 / 05期

关键词：

c-Myc; G-quadruplex; telomerase; triethylene tetraamine;

D O I：

10.1093/jb/mvm069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III1 (NHE III1) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III1 element, and inhibits the expression of c-myc in HeLa cells.

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收藏

页码：669 / 674

页数：6

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