Cholesterol esterase activity of a molecularly imprinted polymer

被引：1
|
作者：
Kim, JM [1 ]
Ahn, KD
Wulff, G
机构：
[1] Univ Dusseldorf, Inst Organ Chem & Macromol Chem, D-40225 Dusseldorf, Germany
[2] Korea Inst Sci & Technol, Funct Polymer Lab, Div Life Sci, Seoul 130650, South Korea
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2001年 / 202卷 / 07期
关键词：
D O I：
10.1002/1521-3935(20010401)202:7<1105::AID-MACP1105>3.0.CO;2-P
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A molecular imprinted polymer with cholesterol esterase activity was prepared. Polymerization of N,N′-diethyl(4-vinylphenyl)amidine in the presence of the phosphate transition state analogue 2 followed by removal of the print molecule generated a catalytically active polymer with Km of 3.7 mM and Kcat of 2.2·10-4 min-1, respectively. A relative rate enhancement of 27-fold in the presence of the control polymer were observed.
引用
收藏
页码：1105 / 1108
页数：4
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