Persistent blood DNA methylation changes one year after SARS-CoV-2 infection

被引：26

作者：

Balnis, Joseph ^{[1
,2
]}

Madrid, Andy ^{[3
]}

Hogan, Kirk J. ^{[4
]}

Drake, Lisa A. ^{[1
]}

Adhikari, Anish ^{[1
,2
]}

Vancavage, Rachel ^{[1
,2
]}

Singer, Harold A. ^{[1
]}

Alisch, Reid S. ^{[3
]}

Jaitovich, Ariel ^{[1
,2
]}

机构：

[1] Albany Med Coll, Div Pulm & Crit Care Med, Albany, NY 12208 USA

[2] Albany Med Coll, Dept Mol & Cellular Physiol, 47 New Scotland Ave,MC91, Albany, NY 12208 USA

[3] Albany Med Coll, Dept Neurol Surg, Madison, WI USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Anesthesiol, Madison, WI USA

来源：

CLINICAL EPIGENETICS | 2022年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COVID-19; DNA methylation; SARS; PASC;

D O I：

10.1186/s13148-022-01313-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fifteen participants previously hospitalized for SARS-CoV-2 infection were epityped one year after discharge. Of the 1505 acute illness-induced differentially methylated regions (DMRs) previously identified, we found 71 regions with persisted differentially methylated, with an average of 7 serial CpG positions per DMR. Sixty-four DMRs persisted hypermethylated, and 7 DMR persisted hypomethylated. These data are the first reported evidence that DNA methylation changes in circulating leukocytes endure long after recovery from acute illness.

引用

页数：5

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