Spiro-heterocycles: A convenient synthesis and antimicrobial activity of some 3-(5-aryl/aryloxymethyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1′,2-thiazolidin-4-ones

被引：0

作者：

Begum, Kahkashan ^{[1
]}

Ahmad, Akeel ^{[2
]}

Tiwari, Shailendra ^{[3
]}

机构：

[1] Gandhi Faiz E Aam Coll, Dept Chem, Shahjahanpur 242001, India

[2] Mirza Ghalib Coll, Dept Chem, Gaya 823001, India

[3] Univ Allahabad, Dept Chem, Allahabad 211002, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2021年 / 60卷 / 11期

关键词：

Substituted aryl/aryloxymethyl; 1,3,4-thiadiazole; spiro-cyclohexane; antimicrobial activity; antifungal activity; ANTITUBERCULOSIS ACTIVITY; ANTIBACTERIAL ACTIVITY; DERIVATIVES; THIAZOLIDINONE; 4-THIAZOLIDINONE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of novel 3-(5-aryl/aryloxy methyl-1,3,4-thiadiazol-2-yl)-spiro-cyclohexane-1'2-thiazolidin-4-ones have been synthesized from a common intermediate, in good yields. These compounds have been screened for their antibacterial and antifungal activity against different pathogenic strains of bacteria and fungi. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined for the test compounds as well as for reference standards. Compounds 3c, 3d, 6c and 6d have shown good antibacterial activity where as compounds 3a, 3b, 6a and 6b have displayed better antifungal activity.

引用

页码：1490 / 1495

页数：6

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