Tumor Microenvironment, Metabolism, and Immunotherapy

被引：203
作者：
DeBerardinis, Ralph J. [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Childrens Med Res Inst, Dallas, TX 75390 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 09期
关键词：
GLUTAMINE;
D O I：
10.1056/NEJMcibr1914890
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The newly diversified experimental strategies to treat cancer include those that involve tweaks to host immunity. A recently described strategy, conducted in mouse models of cancer, targets tumor cells while simultaneously boosting T-cell function.
引用
收藏
页码：869 / 871
页数：3
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  • [4] The Emerging Hallmarks of Cancer Metabolism
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    Thompson, Craig B.
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    Lewis, Jason S.
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