Autophagy fights disease through cellular self-digestion

被引：5557

作者：

Mizushima, Noboru ^{[4
]}

Levine, Beth ^{[5
,6
]}

Cuervo, Ana Maria ^{[7
,8
,9
]}

Klionsky, Danial J. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[4] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan

[5] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[6] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[7] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat, Bronx, NY 10461 USA

[8] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Biol Struct, Bronx, NY 10461 USA

[9] Yeshiva Univ Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Dev & Mol Biol, Bronx, NY 10461 USA

来源：

NATURE | 2008年 / 451卷 / 7182期

关键词：

D O I：

10.1038/nature06639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.

引用

页码：1069 / 1075

页数：7

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