Adiponectin in renal fibrosis

被引：29
作者：
Jing, Huan [1 ,2 ]
Tang, Simin [1 ,2 ]
Lin, Sen [3 ]
Liao, Meijuan [3 ]
Chen, Hongtao [4 ]
Fan, Youling [5 ]
Zhou, Jun [1 ,2 ]
机构：
[1] Southern Med Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
[2] Zunyi Med Univ, Guangzhou, Guangdong, Peoples R China
[3] First Peoples Hosp Foshan, Foshan, Guangdong, Peoples R China
[4] Guangzhou Eighth Peoples Hosp, Guangzhou, Guangdong, Peoples R China
[5] Panyu Cent Hosp, Guangzhou, Guangdong, Peoples R China
来源：
AGING-US | 2020年 / 12卷 / 05期
关键词：
adiponectin; renal fibrosis; ACTIVATED PROTEIN-KINASE; CHRONIC KIDNEY-DISEASE; SERUM ADIPONECTIN; DIABETIC-NEPHROPATHY; URINARY ADIPONECTIN; OXIDATIVE STRESS; PPAR-GAMMA; INJURY; RECEPTORS; CELLS;
D O I：
10.18632/aging.102811
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Renal fibrosis is an inevitable consequence of parenchymal scarring and is the common final pathway that mediates almost all progressive renal diseases. Adiponectin, a hormone produced by adipose tissue, possesses potent anti-insulin, anti-inflammatory, and anti-fibrotic properties. Reportedly, adiponectin serves as an important messenger that facilitates complex interactions between adipose tissue and other metabolically related organs. In recent years, a growing body of evidence supports adiponectin involvement in renal fibrosis. These studies provide a deeper understanding of the molecular mechanism of action of adiponectin in renal fibrosis and also offer a potential preventive and therapeutic target for renal fibrosis. In this review, the physiological role of adiponectin is briefly introduced, and then the mechanism of adiponectin-mediated renal fibrosis and the related signaling pathways are described. Finally, we summarize the findings regarding the clinical value of adiponectin in renal fibrotic diseases and prospected its application potential.
引用
收藏
页码：4660 / 4672
页数：13
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