Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

被引:15
作者
Borhis, Gwenoline [1 ,2 ,3 ]
Richard, Yolande [1 ,2 ,3 ]
机构
[1] INSERM, Cochin Inst, U1016, Dept Infect Immun & Inflammat, F-75014 Paris, France
[2] CNRS, Paris UMR8104, F-75700 Paris, France
[3] Univ Paris 05, Sorbonne Paris Cite, F-75014 Paris, France
关键词
Memory B cells; MZ B-cells; BAFF; B-reg; Virus; Parasite; SIMIAN IMMUNODEFICIENCY VIRUS; SPLENIC MARGINAL ZONE; T FOLLICULAR HELPER; CHRONIC HEPATITIS-C; EPSTEIN-BARR-VIRUS; GERMINAL CENTER B; HIV-1; INFECTION; CUTTING EDGE; ACTIVATING FACTOR; MYCOBACTERIUM-TUBERCULOSIS;
D O I
10.1186/s12865-015-0079-y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent studies on HIV infection have identified new human B-cell subsets with a potentially important impact on anti-viral immunity. Current work highlights the occurrence of similar B-cell alterations in other viral, bacterial, and parasitic infections, suggesting that common strategies have been developed by pathogens to counteract protective immunity. For this review, we have selected key examples of human infections for which B-cell alterations have been described, to highlight the similarities and differences in the immune responses to a variety of pathogens. We believe that further comparisons between these models will lead to critical progress in the understanding of B-cell mechanisms and will open new target avenues for therapeutic interventions.
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页数:10
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