Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora

被引：25

作者：

Chen, Jia ^{[1
]}

Lv, Zhiming ^{[1
]}

Cheng, Ziyang ^{[1
]}

Wang, Tiancheng ^{[1
]}

Li, Peng ^{[1
]}

Wu, Aibo ^{[3
]}

Nepovimova, Eugenie ^{[4
]}

Long, Miao ^{[1
]}

Wu, Wenda ^{[2
,4
]}

Kuca, Kamil ^{[4
,5
]}

机构：

[1] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110866, Peoples R China

[2] Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China

[3] Chinese Acad Sci, Univ Chinese Acad Sci, SIBS UGENT SJTU Joint Lab Mycotoxin Res, Shanghai Inst Nutr & Hlth,CAS Key Lab Nutr Metab, Shanghai 200031, Peoples R China

[4] Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech Republic

[5] Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove, Czech Republic

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 156卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Aflatoxin B1; Bacillus amyloliquefaciens B10; Intestinal flora; Tight junction protein; SUBTILIS SPORES; LACTOBACILLUS; PERFORMANCE; B-1; SUPPLEMENTATION; MICROBIOTA; MECHANISM; BACTERIA;

D O I：

10.1016/j.fct.2021.112438

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus amyloliquefaciens B10 could significantly improve the effects of AFB1 on body weight and intestinal inflammation of mice and enhance the expression of tight-junction protein. Compared with the CON group, the combination of AFB1 and B10 significantly increased the abundance of Actinobacteria and Bacilli in a collaborative manner, and significantly reduced the abundance of Ruminococcae, Lactobacillaceae and Clostridia. Meanwhile, the results showed that the abundance of Bacterides and Bacterdia in AFB1 + B10 group was significantly lower than that of AFB1 group, and the Firmicutes increased significantly. Bacillus amyloliquefaciens B10 can be used as a feed additive and alleviate cecal inflammation induced by AFB1 in mice by regulating intestinal flora.

引用

页数：11

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