Synthesis, characterization, crystal structure and antiproliferative in vitro activity of long-chain aliphatic thiosemicarbazones and their Ni(II) complexes

被引：36

作者：

Belicchi-Ferrari, Marisa ^{[1
]}

Bisceglie, Franco ^{[1
]}

Pelosi, Giorgio ^{[1
]}

Pinelli, Silvana ^{[2
]}

Tarasconi, Pieralberto ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Chim Gen & Inorgan Chim Anal Chim Fi, I-43100 Parma, Italy

[2] Univ Parma, Dipartimento Clin Med Nefrol & Sci Prevenz, I-43100 Parma, Italy

来源：

POLYHEDRON | 2007年 / 26卷 / 17期

关键词：

nickel(II) complexes; thiosemicarbazonato complexes; crystal structure; antineoplastic activity; hydrogen bonding;

D O I：

10.1016/j.poly.2007.07.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the course of a research on metal-based compounds active on white blood cell cancers (leukemia, lymphoma and myeloma) nine aliphatic thiosemicarbazones and their nickel complexes have been synthesized with the aim to test their effect on histiocytic lymphoma U937 cell proliferation. All compounds were characterized by elemental, IR and NMR spectra analyses and for five of the complexes also by X-ray crystallography diffraction analysis. Heptanal thiosemicarbazone and the corresponding nickel complex were chosen after a solubility/stability test to carry out preliminary experiments in vitro on human leukemia cell line U937. The complex possesses a remarkable biological activity in inhibiting cell growth and in inducing apoptosis. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5150 / 5161

页数：12

共 40 条

[1] Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity [J].

Afrasiabi, Z ;

Sinn, E ;

Lin, WS ;

Ma, YF ;

Campana, C ;

Padhye, S .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2005, 99 (07) :1526-1531

[2] POTENTIAL ANTITUMOR AGENTS .2. EFFECTS OF MODIFICATIONS IN SIDE CHAIN OF 1-FORMYLISOQUINOLINE THIOSEMICARBAZONE [J].

AGRAWAL, KC ;

SARTORELLI, AC .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :771-+

[3]

ALTOMARE A, SIR97 NEW PROGRAM SO

[4]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[5]

[Anonymous], 1999, J. Appl. Crystallogr, DOI [DOI 10.1107/S0021889899006020, 10.1107/S0021889899006020]

[6]

ANTHOLINE W, 1977, MOL PHARMACOL, V13, P89

[7] Cu(II) complexes with heterocyclic substituted thiosemicarbazones: The case of 5-formyluracil. Synthesis, characterization, X-ray structures, DNA interaction studies, and biological activity [J].

Baldini, M ;

Belicchi-Ferrari, M ;

Bisceglie, F ;

Pelosi, G ;

Pinelli, S ;

Tarasconi, P .

INORGANIC CHEMISTRY, 2003, 42 (06) :2049-2055

[8] Copper(II) and cobalt(III) pyridoxal thiosemicarbazone complexes with nitroprusside as counterion: Syntheses, electronic properties, and antileukemic activity [J].

Belicchi-Ferrari, M ;

Bisceglie, F ;

Casoli, C ;

Durot, S ;

Morgenstern-Badarau, L ;

Pelosi, G ;

Pilotti, E ;

Pinelli, S ;

Tarasconi, P .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (05) :1671-1675

[9]

BELLETTI D, 1988, 188 CTR STU STRUTT D

[10] Equilibrium and kinetic studies of iron(II) and iron(III) complexes of some alpha(N)-heterocyclic thiosemicarbazones. Reduction of the iron(III) complexes of 2-formylpyridine thiosemicarbazone and 2-acetylpyridine thiosemicarbazone by cellular thiol-like reducing agents [J].

Borges, RHU ;

Paniago, E ;

Beraldo, H .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1997, 65 (04) :267-275

← 1 2 3 4 →