Huntington's Disease: A Review of the Known PET Imaging Biomarkers and Targeting Radiotracers

被引：20

作者：

Cybulska, Klaudia ^{[1
,2
]}

Perk, Lars ^{[2
]}

Booij, Jan ^{[1
,3
]}

Laverman, Peter ^{[1
]}

Rijpkema, Mark ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Dept Radiol & Nucl Med, Med Ctr, Geert Grootepl Zuid 10, NL-6525 EZ Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Radboud Translat Med BV, Geert Grootepl 21,Route 142, NL-6525 EZ Nijmegen, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Radiol & Nucl Med, Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

来源：

MOLECULES | 2020年 / 25卷 / 03期

关键词：

Huntington's disease; mutant huntingtin; Positron Emission Tomography; radiochemistry; fluorine-18; carbon-11; radiopharmaceuticals; C-11]raclopride; F-18]MNI-659; VESICLE GLYCOPROTEIN 2A; IN-VIVO; PHOSPHODIESTERASE; 10A; RECEPTOR-LIGAND; PRECLINICAL EVALUATION; MICROGLIAL ACTIVATION; ADENOSINE RECEPTORS; MOUSE MODEL; DOPAMINE; TOMOGRAPHY;

D O I：

10.3390/molecules25030482

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Huntington's disease (HD) is a fatal neurodegenerative disease caused by a CAG expansion mutation in the huntingtin gene. As a result, intranuclear inclusions of mutant huntingtin protein are formed, which damage striatal medium spiny neurons (MSNs). A review of Positron Emission Tomography (PET) studies relating to HD was performed, including clinical and preclinical data. PET is a powerful tool for visualisation of the HD pathology by non-invasive imaging of specific radiopharmaceuticals, which provide a detailed molecular snapshot of complex mechanistic pathways within the brain. Nowadays, radiochemists are equipped with an impressive arsenal of radioligands to accurately recognise particular receptors of interest. These include key biomarkers of HD: adenosine, cannabinoid, dopaminergic and glutamateric receptors, microglial activation, phosphodiesterase 10 A and synaptic vesicle proteins. This review aims to provide a radiochemical picture of the recent developments in the field of HD PET, with significant attention devoted to radiosynthetic routes towards the tracers relevant to this disease.

引用

页数：21

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