Vitamin D and the vitamin D receptor in liver pathophysiology

被引：65

作者：

Zunigaa, Silvia ^{[1
,2
,3
]}

Firrincieli, Delphine ^{[1
,2
]}

Housset, Chantal ^{[1
,2
,4
]}

Chignard, Nicolas ^{[1
,2
]}

机构：

[1] Univ Paris 06, UMR S 938, CdR St Antoine, F-75005 Paris, France

[2] INSERM, UMR S 938, CdR St Antoine, F-75012 Paris, France

[3] Pontificia Univ Catolica Chile, Santiago, Chile

[4] Hop St Antoine, Serv Hepatol, AP HP, F-75020 Paris, France

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2011年 / 35卷 / 04期

关键词：

PRIMARY BILIARY-CIRRHOSIS; D-BINDING PROTEIN; ISOLATED EPITHELIAL-CELLS; FARNESOID-X-RECEPTOR; CHRONIC HEPATITIS-C; BILE-ACID SYNTHESIS; D NUCLEAR RECEPTOR; GENE POLYMORPHISMS; IN-VITRO; 1,25-DIHYDROXYVITAMIN D-3;

D O I：

10.1016/j.clinre.2011.02.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms of homeostatic control. We will also address the associations between the vitamin D-VDR axis and pathological liver entities, such as non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis and liver cancer. The link between liver diseases and the vitamin D-VDR axis will be discussed in light of evidences arising from in vitro and in vivo studies. Finally, we will consider the therapeutic potential of the vitamin D-VDR axis in liver diseases. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：295 / 302

页数：8

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