The aim of this study is to characterize the particle size distribution and circularity of various Mineral Trioxide Aggregates (MTA) (ProRoot MTA/ MTA Angelus/Gray and White) and Portland cements with effective size ranges of 1.5-160 mu m using a flow particle analyzer (Sysmex FPIA-3000, Kobe, Japan). Cumulative percentage of particles between 6 and 10 mu m were, 65, 73, 48, 53, and 70%, for Gray ProRoot MTA, White ProRoot MTA, Gray MTA Angelus, White MTA Angelus, and Portland cement, respectively. ProRoot MTA contains fewer large particles than MTA Angelus. MTA Angelus contains a higher number of small particles than ProRoot MTA. White MTA contains smaller particles with a narrower range of size distribution than Gray MTA. MTA Angelus particles have relatively low circularity and wide size distribution and are less homogeneous than ProRoot MTA.