Differences in interactions between azole drugs related to modifications in the 14-α sterol dernethylase gene (cyp51A) of Aspergillus fumigatus

被引：25
作者：
Garcia-Effron, G [1 ]
Mellado, E [1 ]
Gomez-Lopez, A [1 ]
Alcazar-Fuoli, L [1 ]
Cuenca-Estrella, A [1 ]
Rodriguez-Tudela, JL [1 ]
机构：
[1] Ctr Nacl Microbiol Virol & Inmunol Sanitarias Maja, Microbiol Serv, Inst Salud Carlos III, Madrid 28220, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 05期
关键词：
D O I：
10.1128/AAC.49.5.2119-2121.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.
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页码：2119 / 2121
页数：3
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