Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides

被引：63

作者：

McDougal, Nolan T. ^{[1
]}

Streuff, Jan ^{[1
]}

Mukherjee, Herschel ^{[1
]}

Virgil, Scott C. ^{[1
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Labs Chem Synth, Pasadena, CA 91125 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 42期

关键词：

ENANTIOSELECTIVE HECK REACTIONS; CATALYZED ALLYLIC SUBSTITUTION; OXAZOLINE-CONTAINING LIGANDS; DIELS-ALDER REACTIONS; ASYMMETRIC CATALYSIS; DECARBOXYLATIVE PROTONATION; CHIRAL LIGANDS; ALLYLATION; COMPLEXES; ARYLATION;

D O I：

10.1016/j.tetlet.2010.08.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5550 / 5554

页数：5

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