Long-term Survival Outcomes of Primary Breast Cancer in Women With or Without Preoperative Magnetic Resonance Imaging: A Matched Cohort Study

被引：22

作者：

Choi, W. J. ^{[1
]}

Cha, J. H. ^{[1
]}

Kim, H. H. ^{[1
]}

Shin, H. J. ^{[1
]}

Chae, E. Y. ^{[1
]}

Jung, K. H. ^{[2
]}

Ahn, J. -H. ^{[2
]}

Kim, S. -B. ^{[2
]}

Son, B. H. ^{[3
]}

Ahn, S. H. ^{[3
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol,Res Inst Radiol, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Seoul, South Korea

来源：

CLINICAL ONCOLOGY | 2017年 / 29卷 / 10期

关键词：

Breast cancer; magnetic resonance imaging; recurrence; survival; ADJUVANT BREAST; RECURRENCE; MRI; CARCINOMA; METAANALYSIS; PROGNOSIS; RADIATION; THERAPY; IMPACT; RISK;

D O I：

10.1016/j.clon.2017.06.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims: To investigate whether preoperative magnetic resonance imaging (MRI) in patients with primary breast cancer is predictive of disease-free (DFS) and overall survival and to determine the prognostic factors indicating survival. Materials and methods: This retrospective study was approved by the institutional review board and the requirement for informed consent was waived. From 2009 to 2010, 828 women with primary breast cancer and preoperative MRI were matched with 1613 women without such imaging. Patients were matched with regards to 25 patient and tumour-related covariates. A Cox proportional hazards model was used to investigate the time to recurrence and to estimate the hazard ratio for preoperative MRI. Log-rank tests and Cox proportional hazards survival analysis were carried out on total recurrence DFS and overall survival in the unmatched datasets. Results: In total, 799 matched pairs were available for survival analysis. The MRI group showed a tendency towards better survival outcome; however, there were no significant differences in DFS and overall survival. Age at diagnosis (DFS hazard ratio = 0.98; overall survival hazard ratio = 1.04), larger tumour size (DFS hazard ratio = 1.01; overall survival hazard ratio = 1.02), triple negative breast cancer (DFS hazard ratio = 2.64; overall survival hazard ratio = 3.44) and the presence of lymphovascular invasion (DFS hazard ratio = 2.12; overall survival hazard ratio = 2.70) were independent significant variables for worse DFS and overall survival. Conclusion: Preoperative MRI did not result in an improvement in a patient's outcome. Age at diagnosis, tumour size, molecular subtype and lymphovascular invasion were significant independent factors affecting both DFS and overall survival. (C) 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：653 / 661

页数：9

共 34 条

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