Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia

被引：181

作者：

Kuhn, J. ^{[1
]}

Hardenacke, K. ^{[1
]}

Lenartz, D. ^{[2
]}

Gruendler, T. ^{[1
,3
,4
]}

Ullsperger, M. ^{[4
,5
]}

Bartsch, C. ^{[1
]}

Mai, J. K. ^{[6
]}

Zilles, K. ^{[7
,8
]}

Bauer, A. ^{[7
,9
]}

Matusch, A. ^{[7
]}

Schulz, R-J ^{[10
,11
]}

Noreik, M. ^{[10
,11
]}

Buehrle, C. P. ^{[2
]}

Maintz, D. ^{[12
]}

Woopen, C. ^{[13
]}

Haeussermann, P. ^{[14
]}

Hellmich, M. ^{[15
]}

Klosterkotter, J. ^{[1
]}

Wiltfang, J. ^{[16
]}

Maarouf, M. ^{[17
]}

Freund, H-J ^{[6
]}

Sturm, V. ^{[2
]}

机构：

[1] Univ Cologne, Dept Psychiat & Psychotherapy, D-50937 Cologne, Germany

[2] Univ Cologne, Dept Funct Neurosurg & Stereotaxy, D-50937 Cologne, Germany

[3] Univ Magdeburg, Fac Econ, D-39106 Magdeburg, Germany

[4] Ctr Behav Brain Sci, Magdeburg, Germany

[5] Univ Magdeburg, Inst Psychol, D-39106 Magdeburg, Germany

[6] Univ Dusseldorf, Dept Neuroanat, Dusseldorf, Germany

[7] Res Ctr Juelich, Inst Neurosci & Med, Julich, Germany

[8] Rhein Westfal TH Aachen, Univ Hosp Psychiat, Psychotherapy & Psychosomat, Aachen, Germany

[9] Univ Dusseldorf, Fac Med, Dept Neurol, Dusseldorf, Germany

[10] Univ Cologne, Dept Geriatr, D-50931 Cologne, Germany

[11] Univ Cologne, St Marien Hosp, D-50931 Cologne, Germany

[12] Univ Cologne, Dept Radiol, D-50931 Cologne, Germany

[13] Univ Cologne, Res Unit Eth, Inst Hist Med & Med Eth, D-50931 Cologne, Germany

[14] LVR Clin Cologne, Dept Gerontopsychiat, Cologne, Germany

[15] Univ Cologne, Inst Med Stat Informat & Epidemiol, D-50931 Cologne, Germany

[16] Univ Gottingen, Univ Med Ctr, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany

[17] Klinikum Merheim, Dept Stereotaxy & Funct Neurosurg, Cologne, Germany

来源：

MOLECULAR PSYCHIATRY | 2015年 / 20卷 / 03期

关键词：

SENILE-DEMENTIA; CHOLINERGIC INNERVATION; COGNITIVE IMPAIRMENT; PARKINSONS-DISEASE; MEMORY ENHANCEMENT; FOREBRAIN; EXPRESSION; CORTEX; NEURONS; PATIENT;

D O I：

10.1038/mp.2014.32

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholinergic neurons of the medial forebrain are considered important contributors to brain plasticity and neuromodulation. A reduction of cholinergic innervation can lead to pathophysiological changes of neurotransmission and is observed in Alzheimer's disease. Here we report on six patients with mild to moderate Alzheimer's disease (AD) treated with bilateral low-frequency deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM). During a four-week double-blind sham-controlled phase and a subsequent 11-month follow-up open label period, clinical outcome was assessed by neuropsychological examination using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome measure. Electroencephalography and [F-18]-fluoro-desoxyglucose positron emission tomography were, besides others, secondary endpoints. On the basis of stable or improved primary outcome parameters twelve months after surgery, four of the six patients were considered responders. No severe or nontransitional side effects related to the stimulation were observed. Taking into account all limitations of a pilot study, we conclude that DBS of the NBM is both technically feasible and well tolerated.

引用

页码：353 / 360

页数：8

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