The cap-to-tail guide to mRNA turnover

被引：636
作者：
Wilusz, CJ
Wormington, M
Peltz, SW [1 ]
机构：
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
[2] PTC Therapeut, S Plainfield, NJ 07080 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 04期
关键词：
D O I：
10.1038/35067025
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at which the mRNA decays. Because decay rates affect the expression of specific genes, they provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant mRNAs - including several encoding cytokines, growth factors and proto-oncogenes - are regulated by differential RNA stability. But what are the sequence elements and factors that control the half-lives of mRNAs?
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页码：237 / 246
页数：10
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