The cap-to-tail guide to mRNA turnover

被引：636
作者：
Wilusz, CJ
Wormington, M
Peltz, SW [1 ]
机构：
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
[2] PTC Therapeut, S Plainfield, NJ 07080 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 04期
关键词：
D O I：
10.1038/35067025
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at which the mRNA decays. Because decay rates affect the expression of specific genes, they provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant mRNAs - including several encoding cytokines, growth factors and proto-oncogenes - are regulated by differential RNA stability. But what are the sequence elements and factors that control the half-lives of mRNAs?
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页码：237 / 246
页数：10
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共 113 条
  • [1] A doughnut-shaped heteromer of human Sm-like proteins binds to the 3′-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro
    Achsel, T
    Brahms, H
    Kastner, B
    Bachi, A
    Wilm, M
    Lührmann, R
    [J]. EMBO JOURNAL, 1999, 18 (20) : 5789 - 5802
  • [2] The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex
    Anderson, JSJ
    Parker, R
    [J]. EMBO JOURNAL, 1998, 17 (05) : 1497 - 1506
  • [3] ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells
    Antic, D
    Lu, N
    Keene, JD
    [J]. GENES & DEVELOPMENT, 1999, 13 (04) : 449 - 461
  • [4] Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
    Applequist, SE
    Selg, M
    Raman, C
    Jack, HM
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (04) : 814 - 821
  • [5] ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
    Bakheet, T
    Frevel, M
    Williams, BRG
    Greer, W
    Khabar, KSA
    [J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (01) : 246 - 254
  • [6] A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates
    Bashkirov, VI
    Scherthan, H
    Solinger, JA
    Buerstedde, JM
    Heyer, WD
    [J]. JOURNAL OF CELL BIOLOGY, 1997, 136 (04) : 761 - 773
  • [7] BEELMAN CA, 1994, J BIOL CHEM, V269, P9687
  • [8] An essential component of the decapping enzyme required for normal rates of mRNA turnover
    Beelman, CA
    Stevens, A
    Caponigro, G
    LaGrandeur, TE
    Hatfield, L
    Fortner, DM
    Parker, R
    [J]. NATURE, 1996, 382 (6592) : 642 - 646
  • [9] THE POLY(A)-POLY(A)-BINDING PROTEIN COMPLEX IS A MAJOR DETERMINANT OF MESSENGER-RNA STABILITY INVITRO
    BERNSTEIN, P
    PELTZ, SW
    ROSS, J
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (02) : 659 - 670
  • [10] Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
    Bhattacharya, A
    Czaplinski, K
    Trifillis, P
    He, F
    Jacobson, A
    Peltz, SW
    [J]. RNA, 2000, 6 (09) : 1226 - 1235
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