Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells

被引：15
作者：
Lee, Sun Young [1 ]
Lee, Ha Young [1 ]
Kim, Sang Doo [1 ]
Shim, Jae Mloong [1 ]
Bae, Yoe-Sik [1 ]
机构：
[1] Dong A Univ, Coll Med, Dept Biochem, Pusan 602714, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 363卷 / 03期
关键词：
lysophosphatidylglycerol; endothelial cells; chemotaxis; tube formation; extracellular signal-regulated protein kinase;
D O I：
10.1016/j.bbrc.2007.08.194
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we observed that lysophosphatidylglycerol (LPG) stimulates extracellular signal-regulated kinase (ERK) in human umbilical vein endothelial cells (HUVECs). LPG-stimulated ERK activity was not inhibited by pertussis toxin (PTX), indicating PTX-sensitive G-proteins-independent manner. In terms of functional aspect, LPG induced chemotactic migration of HUVECs in a PTX-insensitive manner. Preincubation of HUVECs with an ERK inhibitor (PD98059) completely inhibited LPG-induced chemotactic migration, suggesting the crucial role of ERK in the process. LPG-induced ERK activation and chemotactic migration in HUVECs were not affected by an lysophosphatidic acid receptor-selective antagonist (Ki16425), indicating lysophosphatidic acid receptors-independency. We also found that LPG stimulated tube formation in HUVECs. Taken together we suggest that LPG stimulates HUVECs and result in chemotactic migration and tube formation, suggesting a new aspect of LPG as a modulator of endothelial cell functioning. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：490 / 494
页数：5
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