Developments in Neuroprotection for HIV-Associated Neurocognitive Disorders (HAND)

被引：25

作者：

Kolson, Dennis L. ^{[1
]}

机构：

[1] Univ Penn, Dept Neurol, Room 280C Clin Res Bldg,415 Curie Blvd, Philadelphia, PA 19104 USA

来源：

CURRENT HIV/AIDS REPORTS | 2022年 / 19卷 / 05期

关键词：

HIV-associated neurocognitive disorders; HAND; Neuroprotection; HIV; Treatment; Brain; COMBINATION ANTIRETROVIRAL THERAPY; CENTRAL-NERVOUS-SYSTEM; CNS PENETRATION-EFFECTIVENESS; SUPPRESSED CHRONIC HIV; IMMUNE ACTIVATION; MICROBIAL TRANSLOCATION; CEREBROSPINAL-FLUID; OXIDATIVE STRESS; HEME OXYGENASE-1; TREATMENT INTENSIFICATION;

D O I：

10.1007/s11904-022-00612-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of Review Reducing the risk of HIV-associated neurocognitive disorders (HAND) is an elusive treatment goal for people living with HIV. Combination antiretroviral therapy (cART) has reduced the prevalence of HIV-associated dementia, but milder, disabling HAND is an unmet challenge. As newer cART regimens that more consistently suppress central nervous system (CNS) HIV replication are developed, the testing of adjunctive neuroprotective therapies must accelerate. Recent Findings Successes in modifying cART regimens for CNS efficacy (penetrance, chemokine receptor targeting) and delivery (nanoformulations) in pilot studies suggest that improving cART neuroprotection and reducing HAND risk is achievable. Additionally, drugs currently used in neuroinflammatory, neuropsychiatric, and metabolic disorders show promise as adjuncts to cART, likely by broadly targeting neuroinflammation, oxidative stress, aerobic metabolism, and/or neurotransmitter metabolism. Adjunctive cognitive brain therapy and aerobic exercise may provide additional efficacy. Adjunctive neuroprotective therapies, including available FDA-approved drugs, cognitive therapy, and aerobic exercise combined with improved cART offer plausible strategies for optimizing the prevention and treatment of HAND.

引用

页码：344 / 357

页数：14

共 127 条

[1]

Abrams E, 2021, LANCET HIV, V8, pe3, DOI 10.1016/S2352-3018(20)30280-0

[2] Redox Signaling, Neuroinflammation, and Neurodegeneration [J].

Aguilera, Gabriela ;

Laura Colin-Gonzalez, Ana ;

Rangel-Lopez, Edgar ;

Chavarria, Anahi ;

Santamaria, Abel .

ANTIOXIDANTS & REDOX SIGNALING, 2018, 28 (18) :1626-1651

[3] Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy [J].

Ambrosius, Bjoern ;

Gold, Ralf ;

Chan, Andrew ;

Faissner, Simon .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2019, 6 (03)

[4] Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity [J].

Ambrosius, Bjoern ;

Faissner, Simon ;

Guse, Kirsten ;

von Lehe, Marec ;

Grunwald, Thomas ;

Gold, Ralf ;

Grewe, Bastian ;

Chan, Andrew .

JOURNAL OF NEUROINFLAMMATION, 2017, 14

[5] Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders [J].

Ances, Beau M. ;

Letendre, Scott L. ;

Alexander, Terry ;

Ellis, Ronald J. .

INTERNATIONAL REVIEW OF PSYCHIATRY, 2008, 20 (01) :89-93

[6] Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients [J].

Ancuta, Petronela ;

Kamat, Anupa ;

Kunstman, Kevin J. ;

Kim, Eun-Young ;

Autissier, Patrick ;

Wurcel, Alysse ;

Zaman, Tauheed ;

Stone, David ;

Mefford, Megan ;

Morgello, Susan ;

Singer, Elyse J. ;

Wolinsky, Steven M. ;

Gabuzda, Dana .

PLOS ONE, 2008, 3 (06)

[7]

Angelovich TA, 2021, CURR TOP BEHAV NEURO, V50, P3, DOI 10.1007/7854_2019_126

[8] Updated research nosology for HIV-associated neurocognitive disorders [J].

Antinori, A. ;

Arendt, G. ;

Becker, J. T. ;

Brew, B. J. ;

Byrd, D. A. ;

Cherner, M. ;

Clifford, D. B. ;

Cinque, P. ;

Epstein, L. G. ;

Goodkin, K. ;

Gisslen, M. ;

Grant, I. ;

Heaton, R. K. ;

Joseph, J. ;

Marder, K. ;

Marra, C. M. ;

McArthur, J. C. ;

Nunn, M. ;

Price, R. W. ;

Pulliam, L. ;

Robertson, K. R. ;

Sacktor, N. ;

Valcour, V. ;

Wojna, V. E. .

NEUROLOGY, 2007, 69 (18) :1789-1799

[9] Associative and predictive biomarkers of dementia in HIV-1-infected patients [J].

Bandaru, V. V. R. ;

McArthur, J. C. ;

Sacktor, N. ;

Cutler, R. G. ;

Knapp, E. L. ;

Mattson, M. P. ;

Haughey, N. J. .

NEUROLOGY, 2007, 68 (18) :1481-1487

[10] Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? [J].

Biswas, Subrata Kumar .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016

← 1 2 3 4 5 6 7 8 9 10 →