An Efficient Oxidation of Primary Azides Catalyzed by Copper Iodide: A Convenient Method for the Synthesis of Nitriles

被引：80

作者：

Lamani, Manjunath ^{[1
]}

Prabhu, Kandikere Ramaiah ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 37期

关键词：

azides; copper; nitriles; oxidation; tert-butyl hydroperoxide; AQUEOUS-MEDIUM; PRIMARY AMIDES; NUCLEOPHILIC-SUBSTITUTION; HETEROGENEOUS CATALYST; MOLYBDENUM XANTHATE; TRANSFORMATION; ALDOXIMES; CYANATION; ALDEHYDES; DEHYDRATION;

D O I：

10.1002/anie.201002635

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A wide range of primary azides have been efficiently oxidized by a catalytic amount of CuI and TBHP into their corresponding nitriles in aqueous solution. A variety of oxidizable functional groups were well tolerated under the reaction conditions, and oxidation of secondary azides furnished their corresponding ketones (see scheme; TBHP=tert-butyl hydroperoxide). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6622 / 6625

页数：4

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