Effect of Vitamin D Supplementation on Serum Lipids, Uric Acid and C-reactive Protein in Patients with Type II Diabetes Mellitus

Background: Type II Diabetes Mellitus (T2DM) is a considerable problem of global health, and finding new therapies for treating the disease continues. Recently, attention has been focused on vitamin D as a potential lowering agent of T2DM's risk factors and its complications. The present work was conducted to determine the effect of vitamin D supplements on serum lipids, uric acid, C-Reactive Protein (CRP) and also Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Materials and Methods: Sixty patients with T2DM as well as deficiency of vitamin D and referred to Rasoul-e-Akram Hospital in 2017 were selected by convenience sampling method. To begin the study, patients' demographic information was required, so a questionnaire including age, waist circumference, sex, height, blood pressure and weight was provided. Patients with vitamin D3<30ng/ml were treated by a daily oral dose of 2000 unit of vitamin D supplementary for 12 weeks. Serum levels of triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), fasting blood sugar (FBS) and Hemoglobin A1C (HbA1C) were measured before and after vitamin D intake. Analysis of data was carried out through the Software Package SPSS Ver. 24. Results: Sixty-five percent of study population (39 people) was composed of females. The mean value +/- standard deviation (SD) amount of age and BMI were 46.8 +/- 8.9 years and 28.4 +/- 4.3 m(2)/kg. The mean +/- SD systolic blood pressure (SBP), 19.3 +/- 122.8 mmHg and diastolic blood pressure (DBP) were 14.1 +/- 79 mmHg. The mean +/- SD of vitamin D in patients was 11.4 +/- 4.5 ng / ml. The comparison of blood factors before and after treatment showed p value> 0.05. Conclusions: Deficiency of vitamin D should be treated and prevented, but administration of this high-dose vitamin D supplements for prevention or improvement of T2DM has not been recommended yet. Our study showed a correlation between the vitamin D intake and decreased level of FBS and Uric Acid in diabetic patients.