FHA Domain pThr Binding Specificity: It's All about Me

被引：7
作者：
Coquelle, Nicolas [1 ]
Glover, J. N. Mark [1 ]
机构：
[1] Univ Alberta, Dept Biochem, Sch Mol & Syst Med, Edmonton, AB T6G 2H7, Canada
来源：
STRUCTURE | 2010年 / 18卷 / 12期
关键词：
RECOGNITION; MOTIF;
D O I：
10.1016/j.str.2010.11.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The FHA domain is a phospho-peptide binding module involved in a wide range of cellular pathways, with a striking specificity for phospho-threonine over phospho-serine binding partners. Biochemical, structural, and dynamic simulations analysis allowed Pennell and colleagues to unravel the molecular basis of FHA domain phospho-threonine specificity.
引用
收藏
页码：1549 / 1550
页数：2
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