Spirostanol tetraglycosides from Ypsilandra thibetica

被引：19

作者：

Lu, Yi ^{[1
,2
]}

Chen, Chang-Xiang ^{[1
]}

Ni, Wei ^{[1
]}

Hua, Yan ^{[2
]}

Liu, Hai-Yang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] SW Forestry Univ, Fac Nat Resources, Kunming 650224, Peoples R China

来源：

STEROIDS | 2010年 / 75卷 / 12期

基金：

中国科学院西部之光基金;

关键词：

Ypsilandra thibetica; Liliaceae; Spirostanol saponins; Ypsilandrosides H-L; STEROIDAL SAPONINS; NMR-SPECTROSCOPY; PARIS-POLYPHYLLA; GLYCOSIDES; RHIZOMES; GROWTH;

D O I：

10.1016/j.steroids.2010.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained five new spirostane glycosides, ypsilandrosides H-L (1-5), and a known saponin polyphylloside III (6). Among them, 1 and 2 are the first spirostane glycosides which possess novel 5(6 -> 7) abeo-steroidal aglycones. Compounds 3 and 4 are rare saponins whose aglycones contain a hydroxyl group at C-7. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analysis and chemical evidences. The isolated compounds were evaluated for their cytotoxic activity on five tumor cell lines. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：982 / 987

页数：6

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