Biomarkers: Mining the biofluid proteome

被引:177
作者
Veenstra, TD
Conrads, TP
Hood, BL
Avellino, AM
Ellenbogen, RG
Morrison, RS
机构
[1] SAIC Frederick Inc, NCI, Lab Prote & Analyt Technol, Frederick, MD 21702 USA
[2] Univ Washington, Sch Med, Dept Neurol Surg, Seattle, WA 98195 USA
关键词
D O I
10.1074/mcp.M500006-MCP200
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry ( MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.
引用
收藏
页码:409 / 418
页数:10
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